Genomics and oncogenesis of childhood brain tumors

This team belongs to the UMR 981 - Molecular predictors and new targets in oncology

The GOBT team is dedicated to understand the development mechanisms of pediatric brain tumors (in particular gliomas). We are looking for biological markers to identify these tumors more precisely, to understand their origin, to define their prognosis and to invent new treatments.

Double strand break repair and Genome Integrity - Lab members

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Lab members

Gerard Mazón (CR, team co-leader)
Eric Le Cam (DR, team co-leader)
Pauline Dupaigne (CR)
Sonia Baconnais (IR)
Clara Basto (PhD Student, UPS)
Amina Serrar (M2 student)
Barbara Ly (M2 Student)
Raquel Iriarte (M1 Student)

We are open for prospective inquires for M2/PhD/Tech positions. Please contact us if you are seeking to apply for competitive calls for post-doctoral positions with a hosting laboratory.

Recent Past members (their current position):

Double strand break repair and Genome Integrity - Publications

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Major publications

1: Muhammad AA, Basto C, Peterlini T, Guirouilh-Barbat J, Thomas M, Veaute X, Busso D, Lopez B, Mazon G, Le Cam E, Masson JY, Dupaigne P. Life Sci Alliance. 2023 Dec 11;7(3):e202201751. doi: 10.26508/lsa.202201751. Print 2024 Mar. PMID: 38081641

Double strand break repair and Genome Integrity - Current research

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Double strand break repair and Genome Integrity Team

This team belongs to the UMR 9019 Genome Integrity and Cancers.

Mechanisms of DNA Repair and Carcinogenesis - Lab members

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Lab members

Murat SAPARBAEV, Research Director, DR1, CNRS;
Alexandre A. ISHCHENKO, Research Director, DR2, CNRS;
Regina GROISMAN, CRCN, INSERM;
Sophie GAD-LAPITEAU, Professor, EPHE ;
Sophie COUVE, Assistant professor, EPHE ;
Flore RENAUD-PAITRA, Assistant professor, EPHE ;
Sophie FERLICOT, PU-PH, clinicien, Université Paris-Saclay ;
Dominique BLUTEAU, Assistant professor, EPHE ;
Kévin BOQUET, technician, EPHE;
Victoria POILLERAT, PhD student, EPHE;

Mechanisms of DNA Repair and Carcinogenesis - Publications

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Major publications

Matkarimov, B.T., Zharkov, D.O., and SAPARBAEV, M.K. (2019) Mechanistic insight into the role of Poly(ADP-ribosyl)ation in DNA topology modulation and response to DNA damage. Mutagenesis, Nov 29. pii: gez045. doi: 10.1093/mutage/gez045/5646155.

Mechanisms of DNA Repair and Carcinogenesis

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Mechanisms of DNA Repair and Carcinogenesis

This team belongs to the UMR 9019 Genome Integrity and Cancers.

4Rs : Réplication, Réparation, Recombinaison and ROS - Lab members

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Lab members

Filippo Rosselli, DR CNRS, Responsable équipe
Corinne Dupuy, DR CNRS
Anne Helbling-Leclerc, MCU Paris Saclay
Stéphane Koundrioukoff, MCU Paris Saclay
Camille Buffet, MCU Sourbonne Université
Jean Feunteun, PU Emerite Paris Saclay
Michelle Debatisse, PU Emerite Sorbonne Université
Frédérique Maczkowiak-Chartois, IE CNRS
Mélanie Schmidt, IE (CDD)

4Rs : Réplication, Réparation, Recombinaison and ROS - Publications

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Major Publications

Oppezzo A, Bourseguin J, Renaud E, Pawlikowska P, Rosselli F. Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia. J Clin Invest. 2020, 130:1377-1391.
Brison O, El-Hilali S, Azar D, Koundrioukoff S, Schmidt M, Nähse V, Jaszczyszyn Y, Lachages AM, Dutrillaux B, Thermes C, Debatisse M, Chen CL. Transcription-mediated organization of the replication initiation program across large genes sets common fragile sites genome-wide. Nat Commun, 2019, 10:5693.